[HTML][HTML] Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin
L-selectin, the leukocyte selectin, mediates the carbohydrate-dependent attachment of
circulating leukocytes to endothelium, preceding emigration into tissues. It functions in
inflammatory leukocyte trafficking and in lymphocyte homing to lymph nodes. From previous
work, the binding of L-selectin to endothelial-associated glycoprotein ligands, GlyCAM-1
and CD34, requires oligosaccharide sialylation, sulfation, and probably fucosylation. We
have recently identified a major capping group in GlyCAM-1 as 6′ sulfated sialyl Lewis x, a …
circulating leukocytes to endothelium, preceding emigration into tissues. It functions in
inflammatory leukocyte trafficking and in lymphocyte homing to lymph nodes. From previous
work, the binding of L-selectin to endothelial-associated glycoprotein ligands, GlyCAM-1
and CD34, requires oligosaccharide sialylation, sulfation, and probably fucosylation. We
have recently identified a major capping group in GlyCAM-1 as 6′ sulfated sialyl Lewis x, a …
