The interaction of the long-acting thyroid stimulator (LATS) with thyroid tissue in vitro
BR Smith - Journal of Endocrinology, 1970 - joe.bioscientifica.com
BR Smith
Journal of Endocrinology, 1970•joe.bioscientifica.comMost of the long-acting thyroid stimulator (LATS)-absorbing activity of human thyroid
homogenates was shown to be in a soluble fraction containing several components
including thyroglobulin, haemoglobulin and serum proteins. Salt precipitation and gel
filtration studies indicated that the absorbing activity was not associated with thyroglobulin of
high molecular weight, but with a 4s fraction. This 4s fraction has been shown to contain
thyroid specific antigens and these may be important in LATS absorption.
homogenates was shown to be in a soluble fraction containing several components
including thyroglobulin, haemoglobulin and serum proteins. Salt precipitation and gel
filtration studies indicated that the absorbing activity was not associated with thyroglobulin of
high molecular weight, but with a 4s fraction. This 4s fraction has been shown to contain
thyroid specific antigens and these may be important in LATS absorption.
Summary
Most of the long-acting thyroid stimulator (LATS)-absorbing activity of human thyroid homogenates was shown to be in a soluble fraction containing several components including thyroglobulin, haemoglobulin and serum proteins. Salt precipitation and gel filtration studies indicated that the absorbing activity was not associated with thyroglobulin of high molecular weight, but with a 4s fraction. This 4s fraction has been shown to contain thyroid specific antigens and these may be important in LATS absorption.
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