Alignment of tropoelastin molecules during the process of elastogenesis is thought to
require fibrillin-containing microfibrils. In this study, we have demonstrated that amino-
terminal domains of two microfibrillar proteins, fibrillin-1 and fibrillin-2, interact with
tropoelastin in solid phase binding assays. The tropoelastin-binding site was localized to a
region beginning at the glycine-rich and proline-rich regions of fibrillin-2 and fibrillin-1,
respectively, and continuing through the second 8-cysteine domain. Characterization of the …