Fibrillin was originally identified as the antigen recognized by monoclonal antibodies
produced after immunization with a preparation of pepsin-resistant peptides extracted from
human amnion. l Previous experience had shown that monoclonal antibody (MAb)
technology could be utilized to advantage to demonstrate the molecular heterogeneity of
connective tissues. 2 We have employed monoclonal antibody technology to circumvent
problems related to the insoluble nature of extracellular connective tissue microfibrils …