Parkinson's disease is a neurodegenerative disorder characterized by progressive
degeneration of dopaminergic (DA) neurons in the substantia nigra. Accumulating evidence
supports the notion that neuroinflammation is involved in the pathogenesis of this disease.
Valproate (VPA) has long been used for the treatment of seizures and bipolar mood
disorder. In vivo and in vitro studies have demonstrated that VPA has neuroprotective and
neurotrophic actions. In this study, using primary neuron–glia cultures from rat midbrain, we …