[HTML][HTML] Bioinformatics approach leads to the discovery of the TMPRSS2: ETS gene fusion in prostate cancer
MA Rubin, AM Chinnaiyan - Laboratory investigation, 2006 - Elsevier
Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We describe the use of a novel bioinformatics approach to discover candidate
oncogenic chromosomal aberrations on the basis of outlier gene expression called COPA
(cancer outlier profile analysis). We demonstrate how this approach led to the identification
of gene fusions of the 5′-untranslated region of TMPRSS2 (21q22. 3), an androgen
regulated gene, with the ETS transcription factor family members, either ERG (21q22. 2) …
carcinomas. We describe the use of a novel bioinformatics approach to discover candidate
oncogenic chromosomal aberrations on the basis of outlier gene expression called COPA
(cancer outlier profile analysis). We demonstrate how this approach led to the identification
of gene fusions of the 5′-untranslated region of TMPRSS2 (21q22. 3), an androgen
regulated gene, with the ETS transcription factor family members, either ERG (21q22. 2) …