Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
Journal of clinical microbiology, 2008•Am Soc Microbiol
Our results show that impairment of the gastrointestinal tracts in human immunodeficiency
virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is
associated with alterations in gut microbiota and intestinal inflammatory parameters. These
findings support the hypothesis that alterations at the gastrointestinal-tract level are a key
factor in HIV pathogenesis.
virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is
associated with alterations in gut microbiota and intestinal inflammatory parameters. These
findings support the hypothesis that alterations at the gastrointestinal-tract level are a key
factor in HIV pathogenesis.
Abstract
Our results show that impairment of the gastrointestinal tracts in human immunodeficiency virus (HIV)-positive patients is present in the early phases of HIV disease. This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis.
American Society for Microbiology