The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas
J Kappler, R Kubo, K Haskins, J White, P Marrack - Cell, 1983 - cell.com
J Kappler, R Kubo, K Haskins, J White, P Marrack
Cell, 1983•cell.comThe receptors for antigen plus a major histocompatibility complex (MHC) gene product on a
T cell hybridoma specific for ovalbumin plus a Class II MHC product were compared with
those on another T cell hybridoma, specific for a Class I MHC product. In each case receptor
material was identified by a clone-specific monoclonal antibody. The two receptors proved to
have very similar gross structures, being 70-85 kd proteins, and reducing to an acidic a-
chain and a slightly basic B-chain, each 40-43 kd. The charge of both the acidic and basic …
T cell hybridoma specific for ovalbumin plus a Class II MHC product were compared with
those on another T cell hybridoma, specific for a Class I MHC product. In each case receptor
material was identified by a clone-specific monoclonal antibody. The two receptors proved to
have very similar gross structures, being 70-85 kd proteins, and reducing to an acidic a-
chain and a slightly basic B-chain, each 40-43 kd. The charge of both the acidic and basic …
Summary
The receptors for antigen plus a major histocompatibility complex (MHC) gene product on a T cell hybridoma specific for ovalbumin plus a Class II MHC product were compared with those on another T cell hybridoma, specific for a Class I MHC product. In each case receptor material was identified by a clone-specific monoclonal antibody. The two receptors proved to have very similar gross structures, being 70-85 kd proteins, and reducing to an acidic a-chain and a slightly basic B-chain, each 40-43 kd. The charge of both the acidic and basic polypeptides varied between the two receptors studied, showing that variable amino acid sequences occur in both chains.
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