Ultraviolet mutagenesis and the SOS response in Escherichia coli: A personal perspective
EM Witkin - Environmental and molecular mutagenesis, 1989 - Wiley Online Library
EM Witkin
Environmental and molecular mutagenesis, 1989•Wiley Online LibraryThe study of ultraviolet (UV) mutagenesis in Escherichia coli began with the assumption that
genes were likely to be changed at the instant of photon absorption. Over many decades, it
became clear that postirradiation cellular activities, including enzymatic DNA repair of UV
photo products and error‐prone modes of tolerating unrepaired DNA lesions can exert
profound influences on the mutagenic outcome of irradiation. Current study focusses on the
molecular details of radiation‐induced translesion DNA replication as the final event in UV …
genes were likely to be changed at the instant of photon absorption. Over many decades, it
became clear that postirradiation cellular activities, including enzymatic DNA repair of UV
photo products and error‐prone modes of tolerating unrepaired DNA lesions can exert
profound influences on the mutagenic outcome of irradiation. Current study focusses on the
molecular details of radiation‐induced translesion DNA replication as the final event in UV …
Abstract
The study of ultraviolet (UV) mutagenesis in Escherichia coli began with the assumption that genes were likely to be changed at the instant of photon absorption. Over many decades, it became clear that postirradiation cellular activities, including enzymatic DNA repair of UV photo products and error‐prone modes of tolerating unrepaired DNA lesions can exert profound influences on the mutagenic outcome of irradiation. Current study focusses on the molecular details of radiation‐induced translesion DNA replication as the final event in UV mutagenesis.
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