Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the
majority of patients with chronic obstructive pulmonary disease (COPD). The molecular
mechanisms leading to steroid resistance are now better understood, and this has identified
new targets for therapy. In patients with severe asthma, several molecular mechanisms have
been identified that might account for reduced steroid responsiveness, including reduced …