[HTML][HTML] Context-dependent cooperation between nuclear factor κB (NF-κB) and the glucocorticoid receptor at a TNFAIP3 intronic enhancer: a mechanism to maintain …
MO Altonsy, SK Sasse, TL Phang, AN Gerber - Journal of Biological …, 2014 - ASBMB
TNF expression is elevated in asthma and other inflammatory airway diseases that are
commonly treated with glucocorticoid-based therapies, but the impact of glucocorticoids on
negative feedback control of TNF is not well understood. We analyzed the effect of
dexamethasone, a potent synthetic glucocorticoid, on TNF-regulated gene expression in
cultured airway epithelial cells. Although dexamethasone-mediated activation of the
glucocorticoid receptor (GR) potently repressed expression of IL1β, IL8, and several other …
commonly treated with glucocorticoid-based therapies, but the impact of glucocorticoids on
negative feedback control of TNF is not well understood. We analyzed the effect of
dexamethasone, a potent synthetic glucocorticoid, on TNF-regulated gene expression in
cultured airway epithelial cells. Although dexamethasone-mediated activation of the
glucocorticoid receptor (GR) potently repressed expression of IL1β, IL8, and several other …