The impact of P2X7 receptor antagonist, brilliant blue G on graft-versus-host disease in mice after allogeneic hematopoietic stem cell transplantation
X Zhong, F Zhu, J Qiao, K Zhao, S Zhu, L Zeng… - Cellular …, 2016 - Elsevier
The purpose of this study was to investigate the role of P2X7 on liver inflammation in mice
after HSCT. Hematopoietic stem cells obtained from C57BL/6 mice were administrated into
BALB/c mice to establish GVHD model. On day 7, 14, 21 and 28 after HSCT, mice received
P2X7R antagonist brilliant blue G (BBG) or not were sacrificed for analysis of weight loss,
liver inflammation, cytokine secretion, P2X7, NLRP3 expression as well as caspase-1
activation. Liver inflammation with neutrophils and macrophases infiltration as well as weight …
after HSCT. Hematopoietic stem cells obtained from C57BL/6 mice were administrated into
BALB/c mice to establish GVHD model. On day 7, 14, 21 and 28 after HSCT, mice received
P2X7R antagonist brilliant blue G (BBG) or not were sacrificed for analysis of weight loss,
liver inflammation, cytokine secretion, P2X7, NLRP3 expression as well as caspase-1
activation. Liver inflammation with neutrophils and macrophases infiltration as well as weight …