Radiation sensitivity and radiation necrosis in the short telomere syndromes
SE Stanley, AD Rao, DL Gable… - International journal of …, 2015 - redjournal.org
We report radiation necrosis as the first manifestation of a germline mutation in telomerase.
A 60-year-old woman presented with defective wound healing after multiple surgical
explorations of the chest wall to exclude breast cancer recurrence. At age 42, she received a
diagnosis of stage I estrogen receptorepositive left breast infiltrating ductal carcinoma on
routine mammography. Lumpectomy with axillary node dissection revealed T1N0 disease.
Her adjuvant radiation therapy consisted of 50.4 Gy in 28 fractions followed by a 10-Gy …
A 60-year-old woman presented with defective wound healing after multiple surgical
explorations of the chest wall to exclude breast cancer recurrence. At age 42, she received a
diagnosis of stage I estrogen receptorepositive left breast infiltrating ductal carcinoma on
routine mammography. Lumpectomy with axillary node dissection revealed T1N0 disease.
Her adjuvant radiation therapy consisted of 50.4 Gy in 28 fractions followed by a 10-Gy …