[HTML][HTML] Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak
IG Winkler, E Wiercinska, V Barbier, B Nowlan… - Experimental …, 2016 - Elsevier
Harvest of granulocyte colony-stimulating factor (G-CSF)-mobilized hematopoietic stem cells
(HSCs) begins at day 5 of G-CSF administration, when most donors have achieved maximal
mobilization. This is based on surrogate markers for HSC mobilization, such as CD34+ cells
and colony-forming activity in blood. However, CD34+ cells or colony-forming units in culture
(CFU-C) are heterogeneous cell populations with hugely divergent long-term repopulation
potential on transplantation. HSC behavior is influenced by the vascular bed in the vicinity of …
(HSCs) begins at day 5 of G-CSF administration, when most donors have achieved maximal
mobilization. This is based on surrogate markers for HSC mobilization, such as CD34+ cells
and colony-forming activity in blood. However, CD34+ cells or colony-forming units in culture
(CFU-C) are heterogeneous cell populations with hugely divergent long-term repopulation
potential on transplantation. HSC behavior is influenced by the vascular bed in the vicinity of …
