Selective bowel decontamination of recipients for prevention against liver injury following orthotopic liver transplantation: evaluation with rat models
M Arai, S Mochida, A Ohno, S Arai, K Fujiwara - Hepatology, 1998 - journals.lww.com
Gut-derived substances can activate Kupffer cells to provoke hepatic necrosis after partial
hepatectomy in rats. A similar situation may occur during orthotopic liver transplantation
(OLT), as congestion in the intestinal wall, caused by portal vein occlusion, is inevitable
during the operation. The contribution of such substances to liver injury following OLT was
investigated in rats. Oral administration of polymyxin B sulfate for 7 days significantly altered
intestinal bacterial flora in rats; Enterobacteriaceae diminished and anaerobes such as …
hepatectomy in rats. A similar situation may occur during orthotopic liver transplantation
(OLT), as congestion in the intestinal wall, caused by portal vein occlusion, is inevitable
during the operation. The contribution of such substances to liver injury following OLT was
investigated in rats. Oral administration of polymyxin B sulfate for 7 days significantly altered
intestinal bacterial flora in rats; Enterobacteriaceae diminished and anaerobes such as …
