Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation
L Wagner, F Kaestner, R Wolf, H Stiller, U Heiser… - Neuropeptides, 2016 - Elsevier
Abstract Background Dipeptidyl peptidase 4 (DPP4; EC 3.4. 14.5; CD26) is a membrane-
bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of
peptides with either proline or alanine at the penultimate position. Substrates of DPP4
include several stress-related neuropeptides implicated in anxiety, depression and
schizophrenia. A decline of DPP4-like activity has been reported in sera from depressed
patient, but not fully characterized regarding DPP4-like enzymes, therapeutic interventions …
bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of
peptides with either proline or alanine at the penultimate position. Substrates of DPP4
include several stress-related neuropeptides implicated in anxiety, depression and
schizophrenia. A decline of DPP4-like activity has been reported in sera from depressed
patient, but not fully characterized regarding DPP4-like enzymes, therapeutic interventions …