Enhanced Y1-receptor-mediated vasoconstrictive action of neuropeptide Y (NPY) in superior mesenteric arteries in portal hypertension
BACKGROUND/AIMS: Vascular hyporeactivity to catecholamines contributes to arterial
vasodilation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (NPY)
is a sympathetic neurotransmitter facilitating adrenergic vasoconstriction via Y1-receptors on
the vascular smooth muscle. Therefore, we investigated its role for vascular reactivity in the
superior mesenteric artery (SMA) of portal vein ligated (PVL) and sham operated rats.
METHODS: In vitro perfused SMA vascular beds of rats were tested for the cumulative dose …
vasodilation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (NPY)
is a sympathetic neurotransmitter facilitating adrenergic vasoconstriction via Y1-receptors on
the vascular smooth muscle. Therefore, we investigated its role for vascular reactivity in the
superior mesenteric artery (SMA) of portal vein ligated (PVL) and sham operated rats.
METHODS: In vitro perfused SMA vascular beds of rats were tested for the cumulative dose …