[HTML][HTML] Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5 …
R Gurung, A Tan, LM Ooms, MJ McGrath… - Journal of Biological …, 2003 - ASBMB
SKIP (skeletal muscle andkidney enriched inositolphosphatase) is a recently identified
phosphatidylinositol 3, 4, 5-trisphosphate-and phosphatidylinositol 4, 5-bisphosphate-
specific 5-phosphatase. In this study, we investigated the intracellular localization of SKIP.
Indirect immunofluorescence and subcellular fractionation showed that, in serum-starved
cells, both endogenous and recombinant SKIP colocalized with markers of the endoplasmic
reticulum (ER). Following epidermal growth factor (EGF) stimulation, SKIP transiently …
phosphatidylinositol 3, 4, 5-trisphosphate-and phosphatidylinositol 4, 5-bisphosphate-
specific 5-phosphatase. In this study, we investigated the intracellular localization of SKIP.
Indirect immunofluorescence and subcellular fractionation showed that, in serum-starved
cells, both endogenous and recombinant SKIP colocalized with markers of the endoplasmic
reticulum (ER). Following epidermal growth factor (EGF) stimulation, SKIP transiently …