[HTML][HTML] Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
KS Kovacina, GY Park, SS Bae, AW Guzzetta… - Journal of Biological …, 2003 - ASBMB
Akt (also called protein kinase B) is one of the major downstream targets of the
phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated in insulin
signaling, stimulation of cellular growth, and inhibition of apoptosis as well as transformation
of cells. Although a number of cellular proteins have been identified as putative targets of the
enzyme, additional substrates may play a role in the varied responses elicited by this
enzyme. We have used a combination of 14-3-3 binding and recognition by an antibody to …
phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated in insulin
signaling, stimulation of cellular growth, and inhibition of apoptosis as well as transformation
of cells. Although a number of cellular proteins have been identified as putative targets of the
enzyme, additional substrates may play a role in the varied responses elicited by this
enzyme. We have used a combination of 14-3-3 binding and recognition by an antibody to …