[HTML][HTML] Autoantibodies toward ATP4A and ATP4B subunits of gastric proton pump H+, K+-ATPase are reliable serological pre-endoscopic markers of corpus atrophic …
E Lahner, I Marzinotto, V Lampasona… - Clinical and …, 2020 - journals.lww.com
METHODS: A prospective case-finding study was performed on 218 naive adult patients
(131 women, median age 65 years) who underwent gastric biopsies to confirm/exclude
CAG. Patients with histopathological CAG were defined as cases, conversely as controls.
Autoantibodies against the individual alpha (ATP4A) and beta (ATP4B) subunits of ATP4
were measured by luciferase immunoprecipitation, and global PCA and pepsinogen I by
enzyme-linked immunosorbent assay. RESULTS: Histopathology classified 107 subjects …
(131 women, median age 65 years) who underwent gastric biopsies to confirm/exclude
CAG. Patients with histopathological CAG were defined as cases, conversely as controls.
Autoantibodies against the individual alpha (ATP4A) and beta (ATP4B) subunits of ATP4
were measured by luciferase immunoprecipitation, and global PCA and pepsinogen I by
enzyme-linked immunosorbent assay. RESULTS: Histopathology classified 107 subjects …