Induced pluripotent stem cells (iPSCs) maintain during the first few culture passages a set of
epigenetic marks and metabolites characteristic of their somatic cell of origin, a concept
defined as epigenetic donor memory. These residual somatic features are lost over time
after extensive culture passaging. Therefore, epigenetic donor memory may be responsible
for the higher differentiation efficiency toward the tissue of origin observed in low passage
iPSCs versus high passage iPSC or iPSCs derived from a different tissue source …