Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant recipients
JD Morrisett, G Abdel-Fattah, BD Kahan - Transplantation Proceedings, 2003 - Elsevier
BACKGROUND: Sirolimus (Rapammune, rapamycin, RAPA) is a strong immunosuppressive
agent that reduces kidney transplant rejection. Hyperlipidemia is a significant side effect of
sirolimus treatment and often leads to vascular disease. We have studied the repeatability,
reversibility, and dose dependence of the plasma lipid and apoprotein changing effects of
sirolimus and attempted to determine the mechanism by which sirolimus induces
hypertriglyceridemia in some kidney transplant recipients. METHODS: Six patients with renal …
agent that reduces kidney transplant rejection. Hyperlipidemia is a significant side effect of
sirolimus treatment and often leads to vascular disease. We have studied the repeatability,
reversibility, and dose dependence of the plasma lipid and apoprotein changing effects of
sirolimus and attempted to determine the mechanism by which sirolimus induces
hypertriglyceridemia in some kidney transplant recipients. METHODS: Six patients with renal …