The relevance of the supramolecular arrangements of the respiratory chain complexes in human diseases and aging
I Ramírez-Camacho, O Flores-Herrera, C Zazueta - Mitochondrion, 2019 - Elsevier
Mitochondrial dysfunction, a common factor in several diseases is accompanied with
reactive oxygen species (ROS) production. These molecules react with proteins and lipids at
their site of generation, establishing a vicious cycle which might result in further
mitochondrial injury. It is well established that mitochondrial respiratory complexes can be
organized into supramolecular structures called supercomplexes (SCs) or respirasomes;
yet, the physiological/pathological relevance of these structures remains unresolved …
reactive oxygen species (ROS) production. These molecules react with proteins and lipids at
their site of generation, establishing a vicious cycle which might result in further
mitochondrial injury. It is well established that mitochondrial respiratory complexes can be
organized into supramolecular structures called supercomplexes (SCs) or respirasomes;
yet, the physiological/pathological relevance of these structures remains unresolved …
