Inhibitors of the HIV-1 capsid, a target of opportunity
SK Carnes, JH Sheehan, C Aiken - Current Opinion in HIV and …, 2018 - journals.lww.com
SK Carnes, JH Sheehan, C Aiken
Current Opinion in HIV and AIDS, 2018•journals.lww.comSmall molecules that bind to the viral capsid protein can be potent inhibitors of HIV infection.
Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing
work in this area is contributing to an understanding of the molecular biology of HIV
uncoating and maturation.
Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing
work in this area is contributing to an understanding of the molecular biology of HIV
uncoating and maturation.
Summary
Small molecules that bind to the viral capsid protein can be potent inhibitors of HIV infection. Capsid-targeting drugs are predicted to exhibit high barriers to viral resistance, and ongoing work in this area is contributing to an understanding of the molecular biology of HIV uncoating and maturation.
Lippincott Williams & Wilkins