Role of glycogen phosphorylase in liver glycogen metabolism
L Agius - Molecular aspects of medicine, 2015 - Elsevier
Liver glycogen is synthesized after a meal in response to an increase in blood glucose
concentration in the portal vein and endocrine and neuroendocrine signals, and is degraded
to glucose between meals to maintain blood glucose homeostasis. Glycogen degradation
and synthesis during the diurnal cycle are mediated by changes in the activities of
phosphorylase and glycogen synthase. Phosphorylase is regulated by phosphorylation of
serine-14. Only the phosphorylated form of liver phosphorylase (GPa) is catalytically active …
concentration in the portal vein and endocrine and neuroendocrine signals, and is degraded
to glucose between meals to maintain blood glucose homeostasis. Glycogen degradation
and synthesis during the diurnal cycle are mediated by changes in the activities of
phosphorylase and glycogen synthase. Phosphorylase is regulated by phosphorylation of
serine-14. Only the phosphorylated form of liver phosphorylase (GPa) is catalytically active …