Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in
several cell types including the brain cells such as neuronal progenitors, neurons,
astrocytes, and oligodendrocytes. Emerging evidence shows that PDGF-mediated signaling
regulates diverse functions in the central nervous system (CNS) such as neurogenesis, cell
survival, synaptogenesis, modulation of ligand-gated ion channels, and development of
specific types of neurons. Interestingly, PDGF/PDFGR signaling can elicit paradoxical roles …