Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity
EA Wilson, H Sun, Z Cui, MT Jahnke… - American Journal …, 2021 - journals.physiology.org
The G-protein subunits Gqα and G11α (Gq/11α) couple receptors to phospholipase C,
leading to increased intracellular calcium. In this study we investigated the consequences of
Gq/11α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of
energy homeostasis. Mice with DMH-specific deletion of Gq/11α (DMHGq/11KO) were
generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent
protein (GFP) into the DMH of Gqαflox/flox: G11α−/− mice. Compared with control mice that …
leading to increased intracellular calcium. In this study we investigated the consequences of
Gq/11α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of
energy homeostasis. Mice with DMH-specific deletion of Gq/11α (DMHGq/11KO) were
generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent
protein (GFP) into the DMH of Gqαflox/flox: G11α−/− mice. Compared with control mice that …
[HTML][HTML] Browning and Beiging of Adipose Tissue: Its Role in the Regulation of Energy Homeostasis and as a Potential Target for Alleviating Metabolic Diseases: Gqα …
EA Wilson, H Sun, Z Cui, MT Jahnke… - American Journal of …, 2021 - ncbi.nlm.nih.gov
The G-protein subunits G q α and G 11 α (G q/11 α) couple receptors to phospholipase C,
leading to increased intracellular calcium. In this study we investigated the consequences of
G q/11 α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of
energy homeostasis. Mice with DMH-specific deletion of G q/11 α (DMHGq/11KO) were
generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent
protein (GFP) into the DMH of G q α flox/flox: G 11 α−/− mice. Compared with control mice …
leading to increased intracellular calcium. In this study we investigated the consequences of
G q/11 α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of
energy homeostasis. Mice with DMH-specific deletion of G q/11 α (DMHGq/11KO) were
generated by stereotaxic injection of adeno-associated virus (AAV)-Cre-green fluorescent
protein (GFP) into the DMH of G q α flox/flox: G 11 α−/− mice. Compared with control mice …
