Go to JCI Insight
Jci spelled out white on transparent.20160208
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews...
    • Biology of familial cancer predisposition syndromes (Feb 2019)
    • Mitochondrial dysfunction in disease (Aug 2018)
    • Lipid mediators of disease (Jul 2018)
    • Cellular senescence in human disease (Apr 2018)
    • Fibrosis (Jan 2018)
    • Glia and Neurodegeneration (Sep 2017)
    • Transplantation (Jun 2017)
    • View all review series...
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Scientific Show Stoppers
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

Jci only white

  • About
  • Editors
  • Consulting Editors
  • For authors
  • Current issue
  • Past issues
  • By specialty
  • Subscribe
  • Alerts
  • Advertise
  • Contact
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • Brief Reports
  • Technical Advances
  • Commentaries
  • Editorials
  • Hindsight
  • Review series
  • Reviews
  • The Attending Physician
  • First Author Perspectives
  • Scientific Show Stoppers
  • Top read articles
  • Concise Communication
Top
  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI
  • Top
  • Footnotes
  • Version history
Advertisement

Corrigendum Free access | 10.1172/JCI91882

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Tsang-Chih Kuo, Ching-Ting Tan, Yi-Wen Chang, Chih-Chen Hong, Wei-Jiunn Lee, Min-Wei Chen, Yung-Ming Jeng, Jean Chiou, Pei Yu, Pai-Sheng Chen, Ming-Yang Wang, Michael Hsiao, Jen-Liang Su, and Min-Liang Kuo

Find articles by Kuo, T. in: JCI | PubMed | Google Scholar

Find articles by Tan, C. in: JCI | PubMed | Google Scholar

Find articles by Chang, Y. in: JCI | PubMed | Google Scholar

Find articles by Hong, C. in: JCI | PubMed | Google Scholar

Find articles by Lee, W. in: JCI | PubMed | Google Scholar

Find articles by Chen, M. in: JCI | PubMed | Google Scholar

Find articles by Jeng, Y. in: JCI | PubMed | Google Scholar

Find articles by Chiou, J. in: JCI | PubMed | Google Scholar

Find articles by Yu, P. in: JCI | PubMed | Google Scholar

Find articles by Chen, P. in: JCI | PubMed | Google Scholar

Find articles by Wang, M. in: JCI | PubMed | Google Scholar

Find articles by Hsiao, M. in: JCI | PubMed | Google Scholar

Find articles by Su, J. in: JCI | PubMed | Google Scholar

Find articles by Kuo, M. in: JCI | PubMed | Google Scholar

First published January 3, 2017 - More info

Published in Volume 127, Issue 1 on January 3, 2017
J Clin Invest. 2017;127(1):402–402. https://doi.org/10.1172/JCI91882.
Copyright © 2017, American Society for Clinical Investigation

First published January 3, 2017 - Version history

Related article:

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility
Tsang-Chih Kuo, … , Jen-Liang Su, Min-Liang Kuo
Tsang-Chih Kuo, … , Jen-Liang Su, Min-Liang Kuo
Category: Research Article

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

  • Text
  • PDF
Abstract

Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a screen of 102 patients with lung cancer, we found that ANGPTL1 expression was inversely correlated with invasion, lymph node metastasis, and poor clinical outcomes. ANGPTL1 suppressed the migratory, invasive, and metastatic capabilities of lung and breast cancer cell lines in vitro and reduced metastasis in mice injected with cancer cell lines overexpressing ANGPTL1. Ectopic expression of ANGPTL1 suppressed the epithelial-to-mesenchymal transition (EMT) by reducing the expression of the zinc-finger protein SLUG. A microRNA screen revealed that ANGPTL1 suppressed SLUG by inducing expression of miR-630 in an integrin α1β1/FAK/ERK/SP1 pathway–dependent manner. These results demonstrate that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG.

Authors

Tsang-Chih Kuo, Ching-Ting Tan, Yi-Wen Chang, Chih-Chen Hong, Wei-Jiunn Lee, Min-Wei Chen, Yung-Ming Jeng, Jean Chiou, Pei Yu, Pai-Sheng Chen, Ming-Yang Wang, Michael Hsiao, Jen-Liang Su, Min-Liang Kuo

×

Original citation: J Clin Invest. 2013;123(3):1082–1095. doi:10.1172/JCI64044.

Citation for this corrigendum: J Clin Invest. 2017;127(1):402. doi:10.1172/JCI91882.

During the assembly of Figure 3H, an incorrect image was inadvertently included for the CL1-5GL/ANGPTL1+pLKO_AS2.neo/SLUG sample in the lower panel. The correct tail vein injection panel is below.

The authors regret the error.

Footnotes

See the related article at Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility.

Version history
  • Version 1 (January 3, 2017): Print issue publication

Article tools

  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI

Go to:

  • Top
  • Footnotes
  • Version history
Advertisement
Advertisement
Follow JCI: Facebook logo white Twitter logo v2 Rss icon
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts