Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility
Tsang-Chih Kuo, Ching-Ting Tan, Yi-Wen Chang, Chih-Chen Hong, Wei-Jiunn Lee, Min-Wei Chen, Yung-Ming Jeng, Jean Chiou, Pei Yu, Pai-Sheng Chen, Ming-Yang Wang, Michael Hsiao, Jen-Liang Su, and Min-Liang Kuo
Find articles by Kuo, T. in: JCI | PubMed | Google Scholar
Find articles by Tan, C. in: JCI | PubMed | Google Scholar
Find articles by Chang, Y. in: JCI | PubMed | Google Scholar
Find articles by Hong, C. in: JCI | PubMed | Google Scholar
Find articles by Lee, W. in: JCI | PubMed | Google Scholar
Find articles by Chen, M. in: JCI | PubMed | Google Scholar
Find articles by Jeng, Y. in: JCI | PubMed | Google Scholar
Find articles by Chiou, J. in: JCI | PubMed | Google Scholar
Find articles by Yu, P. in: JCI | PubMed | Google Scholar
Find articles by Chen, P. in: JCI | PubMed | Google Scholar
Find articles by Wang, M. in: JCI | PubMed | Google Scholar
Find articles by Hsiao, M. in: JCI | PubMed | Google Scholar
Find articles by Su, J. in: JCI | PubMed | Google Scholar
Find articles by Kuo, M. in: JCI | PubMed | Google Scholar
First published January 3, 2017 - More info
J Clin Invest. 2017;127(1):402–402. https://doi.org/10.1172/JCI91882.
Copyright © 2017, American Society for Clinical Investigation
Related article:
Abstract
Angiopoietin-like protein 1 (ANGPTL1) is a potent regulator of angiogenesis. Growing evidence suggests that ANGPTL family proteins not only target endothelial cells but also affect tumor cell behavior. In a screen of 102 patients with lung cancer, we found that ANGPTL1 expression was inversely correlated with invasion, lymph node metastasis, and poor clinical outcomes. ANGPTL1 suppressed the migratory, invasive, and metastatic capabilities of lung and breast cancer cell lines in vitro and reduced metastasis in mice injected with cancer cell lines overexpressing ANGPTL1. Ectopic expression of ANGPTL1 suppressed the epithelial-to-mesenchymal transition (EMT) by reducing the expression of the zinc-finger protein SLUG. A microRNA screen revealed that ANGPTL1 suppressed SLUG by inducing expression of miR-630 in an integrin α1β1/FAK/ERK/SP1 pathway–dependent manner. These results demonstrate that ANGPTL1 represses lung cancer cell motility by abrogating the expression of the EMT mediator SLUG.
Authors
Tsang-Chih Kuo, Ching-Ting Tan, Yi-Wen Chang, Chih-Chen Hong, Wei-Jiunn Lee, Min-Wei Chen, Yung-Ming Jeng, Jean Chiou, Pei Yu, Pai-Sheng Chen, Ming-Yang Wang, Michael Hsiao, Jen-Liang Su, Min-Liang Kuo
Original citation: J Clin Invest. 2013;123(3):1082–1095. doi:10.1172/JCI64044.
Citation for this corrigendum: J Clin Invest. 2017;127(1):402. doi:10.1172/JCI91882.
During the assembly of Figure 3H, an incorrect image was inadvertently included for the CL1-5GL/ANGPTL1+pLKO_AS2.neo/SLUG sample in the lower panel. The correct tail vein injection panel is below.
The authors regret the error.
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)